Pasteurized Orange Juice Rich in Carotenoids Protects Caenorhabditis elegans against Oxidative Stress and β-Amyloid Toxicity through Direct and Indirect Mechanisms

Table 5

Effect of pasteurized juice from ‘Bahia’ and ‘Cara Cara’ oranges on C. elegans paralysis induced by β-amyloid expression.

Strain and conditions	Mean paralysis time ()	% mean paralysis time variation vs. control	value (log rank) POJ^a vs. untreated^b	value (log rank) PBJ^c vs. PCJ^b,d	^e
CL2006 on E. coli OP50
Untreated					84 (3)
2% Bahia		25.0	<0.0001		85 (3)
2% Cara Cara		46.0	<0.0001	<0.0001	84 (3)
CL2006 on E. coli OP50-HK^a
Untreated					86 (3)
2% Bahia		23.0	<0.0001		80 (3)
2% Cara Cara		48.0	<0.0001	<0.0001	82 (3)
CL2006 on control(RNAi)
Untreated					88 (3)
2% Bahia		14.0	<0.0001		89 (3)
2% Cara Cara		15.0	<0.0001	0.5562	89 (3)
CL2006 on skn-1(RNAi)
Untreated					87 (3)
2% Bahia		-6.0	0.0191		88 (3)
2% Cara Cara		-6.1	0.0151	0.8555	89 (3)
CL2006 on daf-16(RNAi)
Untreated					89 (3)
2% Bahia		0.9	0.6016		88 (3)
2% Cara Cara		1.9	0.4024	0.8582	89 (3)
CL2006 on hsf-1(RNAi)
Untreated					88 (3)
2% Bahia		7.2	0.0069		89 (3)
2% Cara Cara		-9.8	<0.0001	<0.0001	89 (3)

HK: heat killed, ^aPOJ, pasteurized orange juice, ^bcomparisons were performed using log-rank (Mantel-Cox) test. ^cPBJ, pasteurized ‘Bahia’ orange juice, ^dPCJ, pasteurized ‘Cara Cara’ orange juice, ^etotal number of animals analyzed. The number in parentheses indicates the number of independent trials.