Melatonin and Docosahexaenoic Acid Decrease Proliferation of PNT1A Prostate Benign Cells via Modulation of Mitochondrial Bioenergetics and ROS Production
Oxygen consumption rate of PNT1A cells after incubations. (a) Basal state (S2), (b) respiratory control ratio (OCR), (c) maximum velocity of respiratory chain (S3U), and (d) mitochondrial bioenergetic reserve capacity (MBRC). Values show the mean of nmol of O2/106 cells/min and SEM. C: control (vehicle incubation); DHA: incubation with 100 μM of DHA for 48 h; MLT: incubation with 1 μM of melatonin for 48 h; DM: coincubation with 100 μM of DHA and 1 μM of melatonin for 48 h. Statistical analysis: (A) different from C; (B) different from DHA; (C) different from MLT. was considered statistically different. Three independent experiments were performed in triplicate for statistical analysis.
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