Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

Figure 3

Nonenzymatic autoxidation of polyunsaturated fatty acids. R is polyunsaturated fatty acids containing phospholipids; R^⋅ is an alkoxyl radical; ROO^⋅ is a peroxyl radical (ROO^⋅); ROOH is a lipid hydroperoxide (ROOH); ROOR is PL-OO^⋅ to the bis-allylic position of another PL to form PL-OO-PL^⋅ dimers; ① means initiation stage; ② means propagation stage; ③ means termination stage.