Betulinic Acid Induces ROS-Dependent Apoptosis and S-Phase Arrest by Inhibiting the NF-κB Pathway in Human Multiple Myeloma

Figure 6

BA inhibited MM xenograft tumor growth in vivo. Tumor-bearing mice were randomly assigned to the control and BA-treated groups. The body weights (a) and tumor volumes (b) were measured every third day. NS indicates no significant difference vs. the control group; . (c) Photographs of isolated tumors. (d) The weights of stripped tumors; . (e) Tumor tissues were stained with Ki-67 and NF-κB p65 via immunohistochemistry. (f) The level of NF-κB p65 in xenograft tumors was assessed by Western blotting.

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