Oxidative Medicine and Cellular Longevity / 2019 / Article / Fig 6

Research Article

Salidroside Delays Cellular Senescence by Stimulating Mitochondrial Biogenesis Partly through a miR-22/SIRT-1 Pathway

Figure 6

SIRT1 inhibitor EX-527 attenuates salidroside- (SAL-) or resveratrol- (RES-) induced increment of mitochondrial biogenesis (a) or decreased ROS production in 50PD 2BS cells (b) and induces an elevation of SA-β-gal activity in SAL-treated 50PD cells (c). EX-527 at 10 μM was added 2 hrs before SAL (10 μM) or RES (10 μM) supplementation in the culture medium and was present for 48 h before harvested. ; .

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.