Salidroside Delays Cellular Senescence by Stimulating Mitochondrial Biogenesis Partly through a miR-22/SIRT-1 Pathway
SIRT1 inhibitor EX-527 attenuates salidroside- (SAL-) or resveratrol- (RES-) induced increment of mitochondrial biogenesis (a) or decreased ROS production in 50PD 2BS cells (b) and induces an elevation of SA-β-gal activity in SAL-treated 50PD cells (c). EX-527 at 10 μM was added 2 hrs before SAL (10 μM) or RES (10 μM) supplementation in the culture medium and was present for 48 h before harvested. ;.
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