IKKβ Inhibitor IMD-0354 Attenuates Radiation Damage in Whole-body X-Irradiated Mice

Figure 6

An analysis of the bone marrow cell NF-κB and IκBα in X-irradiated mice administered IMD-0354. Representative images of NF-κB and IκBα in bone marrow cells collected from 7 Gy X-irradiated mice on day 8 after irradiation are shown. The bone marrow cells in the femurs were collected from irradiated mice with or without IMD-0354 treatment, and the NF-κB and IκBα were evaluated by an LSM 710 laser scanning microscope. Blue: DAPI (nucleus), green: NF-κB, and red: IκBα. The scale bar is 20 μm. White arrows indicate representative cells.