Label-Free Proteomics Revealed Oxidative Stress and Inflammation as Factors That Enhance Chemoresistance in Luminal Breast Cancer

Table 3

Representative biological processes related to proteins upregulated in chemoresistant breast cancer.

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Cytoskeleton remodeling/cell adhesion

Collagen alpha-1(XII) chain, fibronectin, keratin type I cytoskeletal 10, myosin 7, Rho GTPase-activating protein 35, vitronectin

Blood coagulation

Alpha 1-antichymotrypsin, alpha 1-antitrypsin, alpha 2-macroglobulin, antithrombin III, kininogen-1, plasminogen, prothrombin

DNA repair/kinetochore assembly

Centromere/kinetochore protein zw10 homolog, DnaJ homolog subfamily C member 10, LINE-1 type transposase domain-containing protein 1

Oxidative metabolism

Acetyl-CoA carboxylase 1; activator of 90 kDa heat shock protein ATPase homolog 2; acylpyruvase FAHD1, mitochondrial; afamin; alpha 1B-glycoprotein; alpha 2 HS glycoprotein; angiotensinogen; apolipoprotein E; ceruloplasmin; clusterin; dynein heavy chain 10, axonemal; dynein heavy chain 3, axonemal; exocyst complex component 1; haptoglobin; haptoglobin-related protein; hemoglobin subunit alpha; hemoglobin subunit beta; hemopexin; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2; kinectin; nuclear pore complex protein Nup205; nuclear receptor corepressor 2; polypeptide N-acetylgalactosaminyltransferase 3; pregnancy zone protein; prolyl 4 hydroxylase subunit alpha-3; regulator of nonsense transcripts 2; ribose phosphate pyrophosphokinase 3; rod cGMP-specific 3,5-cyclic phosphodiesterase subunit alpha; sarcoplasmic/endoplasmic reticulum calcium ATPase 3; serine/threonine protein kinase WNK2; serine/threonine protein phosphatase 2A, 55 kDa regulatory subunit B alpha isoform; serotransferrin; serum albumin; serum amyloid A-4 protein; serum amyloid P component; synembryn-B; transcriptional repressor p66-alpha; vitamin D-binding protein

Immune response_inflammation

Alpha-1 acid glycoprotein 1, alpha-1 acid glycoprotein 2, apolipoprotein A-I, apolipoprotein A-II, apolipoprotein B-100, C-reactive protein, inter-alpha-trypsin inhibitor heavy chain H1, inter-alpha-trypsin inhibitor heavy chain H2, inter-alpha-trypsin inhibitor heavy chain H4, lumican, son of sevenless homolog 1, transcription factor 4

Immune response_humoral immune response

Ig alpha-1 chain C region, Ig gamma-1 chain C region, Ig gamma-2 chain C region, Ig gamma-3 chain C region, Ig gamma-4 chain C region, Ig heavy chain VI region V35, Ig heavy chain V-II region ARH 77, Ig heavy chain V-III region GAL, Ig heavy chain V-III region TIL, Ig kappa chain C region, Ig kappa chain VI region AU, Ig kappa chain VI region EU, Ig kappa chain VI region Gal, Ig kappa chain VI region Rei, Ig kappa chain V-II region TEW, Ig kappa chain V-III region GOL, Ig kappa chain V-III region NG9 (fragment), Ig kappa chain V-III region SIE, Ig kappa chain V-III region Ti, Ig kappa chain V-III region VG (fragment), Ig lambda-1 chain C regions, Ig lambda-2 chain C regions, Ig lambda-3 chain C regions, Ig mu chain C region, immunoglobulin lambda such as polypeptide 5

Immune response_complement system

C4b-binding protein alpha chain, complement C1q subcomponent subunit B, complement C1q subcomponent subunit C, complement C3, complement C4A, Complement C5, complement component C7, complement factor B, complement factor H, plasma protease C1 inhibitor

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