Understanding of ROS-Inducing Strategy in Anticancer Therapy

Figure 3

Proposed biological pathways related to prooxidative anticancer drugs. Comprehensive illustration of the drug-gene, drug-cell process, and drug-disease relationships for certain anticancer drugs with prooxidative activity (buthionine sulfoximine, cisplatin, doxorubicin, imexon, 2-methoxyestradiol, and motexafin gadolinium). Green and red lines denote the positive and negative effects of each drug, respectively. The legend for the diagrams is located at the bottom part of the figure. Target proteins (red), drug molecules (green), cell processes (yellow), and diseases (purple) are symbolized and organized in a complex biological network.