Understanding of ROS-Inducing Strategy in Anticancer Therapy

Table 1

Mechanism of action of ROS-inducing anticancer drugs.

Name	Mechanism of action	Reference
Direct ROS generation
Motexafin gadolinium	Accepts electrons to form superoxide	[69]
Doxorubicin	Induces chelation of iron to generate hydroxyl radical	[74]
Cisplatin	Damages mtDNA and ETC	[76]
2-Methoxyestradiol	Inhibits ETC complex I	[80]
Antioxidant process inhibition
Buthionine sulfoximine	Binds to enzyme related to GSH synthesis	[101]
Imexon	Binds to thiol to GSH activity disruption	[102, 103]