Understanding of ROS-Inducing Strategy in Anticancer Therapy

Table 2

List of proteins, cell processes, and diseases targeted by anticancer drugs.

Drugs	Target type	Relation	Relation effect	Target
2-Methoxyestradiol	Protein	Expression	Positive	BAX, TP53
			Negative	HIF1A, IL6, PCNA, TNF, VEGFA
		Regulation	Positive	CASP9, MAPK8
			Negative	BCL2, HIF1A, SOD2
	Cell process	Regulation	Positive	Apoptosis, autophagy, cell cycle arrest, cell death, DNA damage, mitochondrial damage, oxidative stress, ROS generation
			Negative	Angiogenesis, cell cycle, cell growth, cell invasion, cell proliferation, cell survival, mitochondrial respiration, tumor growth
	Disease	Regulation	Negative	Atherosclerosis, breast cancer, hepatocellular carcinoma, melanoma, pancreatic cancer
Buthionine sulfoximine	Protein	Expression	Positive	BCL2, HMOX1, JUN, NFE2L2, SOD2, TNF
			Negative	GPX1, IL6, NOS2
		Regulation	Positive	BCL2, CASP3, MAPK14
			Negative	GCLC
	Cell process	Regulation	Positive	Apoptosis, autophagy, cell death, cytotoxicity, DNA damage, lipid peroxidation, oxidative stress, ROS generation
			Negative	Cell growth, cell proliferation, tumor growth
	Disease	Regulation	Positive	Cataract, liver injury, necrosis, neurotoxicity, toxicity
			Negative	Hepatocellular carcinoma, lung cancer
Cisplatin	Protein	Expression	Positive	ABCC1, BAX, BBC3, BECN1, CASP3, CASP8, CASP9, CYCS, DDIT3, FAS, FASLG, GPT, H2AFX, HMOX1, IL1B, IL6, JUN, NFE2L2, NOS2, TNF, TP53
			Negative	BCL2, SOD2, XIAP
		Regulation	Positive	CASP3, CASP7, CYCS, G6PD, MAPK14, MAPK3, MAPK8, TP53
			Negative	SOD1
	Cell process	Regulation	Positive	Apoptosis, autophagy, cell cycle arrest, cell death, cytotoxicity, DNA damage, lipid peroxidation, mitochondrial damage, oxidative stress, ROS generation
			Negative	Angiogenesis, cancer cell growth, cell growth, cell invasion, cell proliferation, cell survival, tumor growth
	Disease	Regulation	Positive	Acute kidney injury, kidney disease, liver injury, necrosis, neurotoxicity, renal dysfunction, toxicity
			Negative	Breast cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, lung cancer, lymphoma, melanoma, metastasis, ovarian cancer, pancreatic cancer
Doxorubicin	Protein	Expression	Positive	ABCC1, BAX, BBC3, BECN1, CASP3, CASP7, CASP8, CASP9, CAT, CYCS, DDIT3, FAS, FASLG, GPX1, H2AFX, HMOX1, IL1B, IL6, MAPK3, MAPK8, NFE2L2, NOS2, SOD1, TNF, TP53
			Negative	BCL2, PCNA, VEGFA, XIAP
		Regulation	Positive	ANXA5, CASP3, CASP7, CASP8, FAS, GPT, IL6, MAPK14, MAPK3, MAPK8, NOS2, TP53
			Negative	HIF1A
	Cell process	Regulation	Positive	Apoptosis, autophagy, cell cycle arrest, cell death, cytotoxicity, DNA damage, lipid peroxidation, mitochondrial damage, oxidative stress, ROS generation
			Negative	Angiogenesis, cancer cell growth, cell growth, cell proliferation, cell survival, DNA repair, mitochondrial respiration, tumor growth
	Disease	Regulation	Positive	Acute kidney injury, kidney disease, liver injury, necrosis, neurotoxicity, renal dysfunction, toxicity
			Negative	Breast cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, lung cancer, lymphoma, melanoma, metastasis, ovarian cancer, pancreatic cancer
Imexon	Protein	Expression	Negative	HIF1A
		Regulation	Positive	CASP3, CASP9
	Cell process	Regulation	Positive	Apoptosis, cell cycle arrest, oxidative stress
			Negative	Cancer cell growth, cell cycle, cell growth, tumor growth
	Disease	Regulation	Negative	Lymphoma, melanoma, multiple myeloma, splenomegaly
Motexafin gadolinium	Protein	Regulation	Negative	HMOX1, TXN
	Cell process	Regulation	Positive	Apoptosis, cell death, cytotoxicity, oxidative stress, ROS generation
			Negative	Cell proliferation, cell survival, DNA repair, tumor growth
	Disease	Regulation	Negative	Atherosclerosis, cerebral neoplasm, glioblastoma, lung cancer, metastasis