ROS-Induced GATA4 and GATA6 Downregulation Inhibits StAR Expression in LPS-Treated Porcine Granulosa-Lutein Cells

<div>LPS stimulates ROS generation in pGL. (a) pGL were treated for 24 h with vehicle control or different concentrations (500, 1000, or 2000 ng/mL) of LPS and 0.4 mM H<sub>2</sub>O<sub>2</sub>. Intracellular ROS were evaluated by H2DCFDA detection, and fluorescent images are shown (scale bar: 30 <i>μ</i>m). (b) After LPS and H<sub>2</sub>O<sub>2</sub> treatment, intracellular ROS levels were evaluated. 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Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: ROS-Induced GATA4 and GATA6 Downregulation Inhibits StAR Expression in LPS-Treated Porcine Granulosa-Lutein Cells 