ROS-Induced GATA4 and GATA6 Downregulation Inhibits StAR Expression in LPS-Treated Porcine Granulosa-Lutein Cells

<div>LPS and H<sub>2</sub>O<sub>2</sub> downregulate the expressions of GATA4 and GATA6, but not NR5A1. (a, b, c) pGL were treated for 24 h with vehicle control or different concentrations (500, 1000, or 2000 ng/mL) of LPS, and GATA4, GATA6, and NR5A1 mRNA levels were examined by RT-qPCR. (d, e, f) pGL were treated for 24 h with vehicle control or different concentrations (0.2 or 0.4 mM) of H<sub>2</sub>O<sub>2</sub>, and GATA4, GATA6, and NR5A1 mRNA levels were examined by RT-qPCR. 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Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: ROS-Induced GATA4 and GATA6 Downregulation Inhibits StAR Expression in LPS-Treated Porcine Granulosa-Lutein Cells 