ROS-Induced GATA4 and GATA6 Downregulation Inhibits StAR Expression in LPS-Treated Porcine Granulosa-Lutein Cells

<div>GATA4 and GATA6 are necessary in StAR expression. (a) pGL were transfected for 24 h with 25 nM nontargeting control siRNA (siControl) or 25 nM siRNA targeting GATA4 (siGATA4) and GATA6 (siGATA6). GATA4 and GATA6 mRNA levels were examined by RT-qPCR. (b) mRNA levels of StAR, NR5A1, CYP11A1, and 3<i>β</i>-HSD were examined by RT-qPCR after GATA4 and GATA6 knockdown. 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: ROS-Induced GATA4 and GATA6 Downregulation Inhibits StAR Expression in LPS-Treated Porcine Granulosa-Lutein Cells 