ROS-Induced GATA4 and GATA6 Downregulation Inhibits StAR Expression in LPS-Treated Porcine Granulosa-Lutein Cells

<div>Elimination of ROS with Vc rescues the expressions of GATA4, GATA6, and StAR after treatment with LPS or H<sub>2</sub>O<sub>2</sub>. (a) pGL were treated for 24 h with vehicle control, LPS (1000 ng/mL), and LPS (1000 ng/mL) with Vc (5 mM). StAR, GATA4, and GATA6 mRNA levels were examined by RT-qPCR. (b) pGL were treated for 24 h with vehicle control, H<sub>2</sub>O<sub>2</sub> (0.4 mM), and H<sub>2</sub>O<sub>2</sub> (0.4 mM) with Vc (5 mM). StAR, GATA4, and GATA6 mRNA levels were examined by RT-qPCR. 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Oxidative Medicine and Cellular Longevity

fig8

Figure 8

Figure 8: ROS-Induced GATA4 and GATA6 Downregulation Inhibits StAR Expression in LPS-Treated Porcine Granulosa-Lutein Cells 