Early Kidney Damage Markers after Deferasirox Treatment in Patients with Thalassemia Major: A Case-Control Study

Table 5

Comparison of urinary renal parameters in 3 age groups.

			Study group
			Deferoxamine	Deferasirox	Control
			Mean ± SD	Mean ± SD	Mean ± SD	value
Age	Under 18 years old ()	U. NGAL				0.331
		U. KIM-1				0.247
		U. IL-18				0.692
		U. CREA			—	0.786
		U. Alb			—	0.571
		U. NGAL/CREA			—	0.664
		U. IL-18/CREA			—	0.386
		U. KIM-1/CREA			—	0.386
		U. Alb/CREA			—	0.828
	18 to 25 years old ()	U. NGAL				0.120
		U. KIM-1				0.583
		U. IL-18				0.608
		U. CREA				0.343
		U. Alb				0.451
		U. NGAL/CREA				0.442
		U. IL-18/CREA				0.884
		U. KIM-1/CREA				0.338
		U. Alb/CREA				0.962
	26 to 35 years old ()	U. NGAL				0.845
		U. KIM-1				0.307
		U. IL-18				0.125
		U. CREA				0.317
		U. Alb				0.101
		U. NGAL/CREA				0.050
		U. IL-18/CREA				0.153
		U. KIM-1/CREA				0.150
		U. Alb/CREA				0.095

NGAL: neutrophil gelatinase-associated lipocalin; KIM-1: Kidney Injury Molecule-1; IL: interleukin; CREA: creatinine; Alb: albumin; U: urinary.