<i>Ziziphus spina-christi</i> Leaf Extract Suppressed Mercury Chloride-Induced Nephrotoxicity via Nrf2-Antioxidant Pathway Activation and Inhibition of Inflammatory and Apoptotic Signaling

<div>Histopathological changes in renal tissue following treatment with <i>Ziziphus spina-christi</i> leaf extract (ZSCLE) and/or mercury chloride (HgCl<sub>2</sub>). Kidney tissues from the control and ZSCLE-treated groups (a and b, respectively) showed normal kidney architecture. In HgCl<sub>2</sub>-treated rats, severe inflammation (red arrow), cytoplasmic vacuolation (black star), severe tubular necrosis and apoptosis (blue star), and congested glomeruli (red star) are shown. Posttreatment of ZSCLE (d) markedly minimized all renal lesions caused by mercury. Hematoxylin and eosin (H&amp;E): 400x magnification.</div>

Oxidative Medicine and Cellular Longevity

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Figure 8

Figure 8: <i>Ziziphus spina-christi</i> Leaf Extract Suppressed Mercury Chloride-Induced Nephrotoxicity via Nrf2-Antioxidant Pathway Activation and Inhibition of Inflammatory and Apoptotic Signaling 

Figure 8 | Ziziphus spina-christi Leaf Extract Suppressed Mercury Chloride-Induced Nephrotoxicity via Nrf2-Antioxidant Pathway Activation and Inhibition of Inflammatory and Apoptotic Signaling 