A Meta-Analysis of Resveratrol Protects against Myocardial Ischemia/Reperfusion Injury: Evidence from Small Animal Studies and Insight into Molecular Mechanisms

Table 1

Characteristics of the in vivo studies included in the meta-analysis.

Author

Year

State

Species

Weight/year

Anesthetic

Animal numbers

I/R duration

Vehicle

Resveratrol treatment

Control

Resveratrol

Dosage

Approach

Time

Dong et al. [10]

2015

China

Rats, SD, M

270-300 g

Pentobarbital

10

10

30 min/2 h

DMSO

10 mg/L

i.p.

60 min before I/R

Cheng et al. [11]

2015

China

Rats, SD, M

250-300 g

Sodium pentobarbital

10

10

30 min/2 h

0.9% NaCl

100 μmol/L

i.v.

5 min before I/R

Li et al. [12]

2014

China

Rats, SD, M

250-300 g

Sodium pentobarbital

10

10

30 min/2 h

0.9% NaCl

100 μmol/L

i.v.

5 min before I/R

Cong et al. [13]

2014

China

Rats, SD, M

250-300 g

Sodium pentobarbital

10

10

30 min/2 h

0.9% NaCl

100 μmol/L

i.v.

5 min before I/R

Du et al. [29]

2014

China

Mice, M

3 months

2% isoflurane

8

8

30 min/24 h

Ethanol

10 mg/L

i.p.

60 min before I/R

Shalwala et al. [28]

2014

USA

Mice, ICR, M

g

Sodium pentobarbital

6

6

30 min/24 h

DMSO

5 mg/L

i.p.

24 h before I/R

Naumenko et al. [30]

2013

Russia

Rats, Wistar, M

g

Urethane

10

9

30 min/2 h

DMSO

10 μmol/L

i.v.

30 min before I/R

Shen et al. [31]

2006

China

Rats, SD, M

275-300 g

Sodium pentobarbital

8

8

30 min/2 h

DMSO

10 μmol/L

i.v.

15 min before I/R

Hung et al. [26]

2004

China

Rats, SD, M

270-300 g

Urethane

8

8

60 min/3 h

DMSO

1 mg/L

i.p.

60 min before I/R

Hale and Kloner [32]

2001

USA

Rabbits, NZW, M

2.2-3.0 kg

Ketamine/xylazine

8

8

30 min/3 h

Ethanol

1.5 mg/L

i.v.

15 min before I/R

SD: Sprague-Dawley rats; ICR: Institute of Cancer Research mice; NZW: New Zealand White rabbit; M: male; DMSO: dimethyl sulfoxide; i.p.: intraperitoneal injection; i.v.: intravenous injection.