Oxidative Medicine and Cellular Longevity / 2019 / Article / Tab 2 / Research Article
A Meta-Analysis of Resveratrol Protects against Myocardial Ischemia/Reperfusion Injury: Evidence from Small Animal Studies and Insight into Molecular Mechanisms Table 2 Characteristics of the ex vivo studies included in the meta-analysis.
Author Year State Species Weight/year Anesthetic Animal numbers I/R duration Vehicle Resveratrol treatment Control Resveratrol Dosage Approach Time Yang et al. [14 ] 2016 China Rats, SD, M 10 weeks Chloral hydrate 10 10 30 min/1 h K-H solution 10 μ mol/L Perfusion 15 min before I/R Liao et al. [15 ] 2014 China Mice, KM, M NA Sodium pentobarbital 6 6 15 min/30 min Ethanol 2.0 mg/kg.d Gavage 6 weeks before I/R Adam et al. [16 ] 2012 Africa Rats, LE, M 9 weeks Sodium pentobarbital 6 6 30 min/1 h K-H solution 10 mmol/L Perfusion 25 min before I/R Mukhopadhyay et al. [33 ] 2010 USA Rats, SD, M 250-300 g Sodium pentobarbital 6 6 30 min/2 h NA 5 mg/kg/d Gavage 21 days before I/R Lekli et al. [34 ] 2009 USA Rats, SD, M 250-300 g Sodium pentobarbital 3 3 30 min/2 h NA 2.5 mg/kg/d Gavage 15 days before I/R Das et al. [35 ] 2006 USA Rats, SD, M 250-300 g Sodium pentobarbital 6 6 30 min/2 h K-H solution 10 μ mol/L Perfusion 20 min before I/R Ray et al. [36 ] 1999 USA Rats, SD, M 275–300 g Sodium pentobarbital 3 3 30 min/2 h K-H solution 10 μ mol/L Perfusion 15 min before I/R
SD: Sprague-Dawley rats; KM: Kun-Ming; M: male; LE: Long-Evans; K-H solution: Krebs-Henseleit solution; DMSO: dimethyl sulfoxide.
