Tetramethylpyrazine Attenuates the Endotheliotoxicity and the Mitochondrial Dysfunction by Doxorubicin via 14-3-3γ/Bcl-2

Figure 2

TMP-treated alleviates vascular tissue’s damage induced by Dox toxicity in mice. (a) The activities of mice’s serum LDH and CK. (b) Serum contents of NO. (c) H&E staining was performed for morphological analysis in the thoracic aortas tissue. Blue arrow: spotty necrosis; Orange arrow: hypertrophy of interstitial cells. (d) TUNEL staining was performed for morphological analysis in the thoracic aortas tissue. Orange arrow: TUNEL-positive cells. Data are presented as the mean ± SEM. for fifteen individual experiments. a: P < 0.01, versus control group; b: P < 0.01, versus Dox group; c: P < 0.01, versus TMP + Dox group.

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