Research Article
Tetramethylpyrazine Attenuates the Endotheliotoxicity and the Mitochondrial Dysfunction by Doxorubicin via 14-3-3γ/Bcl-2
Figure 4
TMP-treated protects HUVECs against the endotheliotoxicity induced by Dox. (a) Cell viability of HUVECs. (b) LDH activities in culture media. (c) Histogram of the caspase-3 activity in HUVECs. (d) Flow cytometry dot plots (x-axis: annexin V-staining, y-axis: PI staining), and the quantitation of apoptotic cells. Data are presented as the mean ± SEM. for eight individual experiments. a: P < 0.01, versus control group; b: P < 0.01, versus Dox group; c: P < 0.01, versus TMP + Dox group.
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