Metabolites of the Nitric Oxide (NO) Pathway Are Altered and Indicative of Reduced NO and Arginine Bioavailability in Patients with Cardiometabolic Diseases Complicated with Chronic Wounds of Lower Extremities: Targeted Metabolomics Approach (LC-MS/MS)

Figure 4

Wound type and intermediates in the arginine/NO pathway: (a) citrulline and gangrene, (b) ADMA and phlegmon, (c) Arg/ADMA and ulceration, and (d) citrulline and ulceration. Data are presented as (a) medians or means with 95% confidence intervals and analyzed using (a) the Mann-Whitney test or -test for independent samples.

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(b)

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