Metabolites of the Nitric Oxide (NO) Pathway Are Altered and Indicative of Reduced NO and Arginine Bioavailability in Patients with Cardiometabolic Diseases Complicated with Chronic Wounds of Lower Extremities: Targeted Metabolomics Approach (LC-MS/MS)

Table 3

Correlation pattern between intermediates in the arginine/NO pathway in patients with cardiometabolic diseases with and without chronic wounds.

Metabolite	Arginine	Citrulline	ADMA	SDMA (log)	Arg/ADMA	Arg/SDMA
Arginine	—	-0.14	-0.15	0.23	—	—
Citrulline	0.20	—	0.81^†	0.85^†	-0.62^†	-0.63^†
ADMA	0.45^†	0.69^†	—	0.84^†	—	—
SDMA (log)	0.28	0.63^†	0.68^†	—	—	—
Arg/ADMA	—	-0.35^‡	—	—	—
Arg/SDMA	—	-0.36^‡	—	—	—	—

The right side of the table (in italics) presents correlations in patients without wounds; the left side (in a straight script) presents correlations in patients with chronic wounds. , , and . Data were analyzed using the Pearson test and reported as correlation coefficients .