HIV-1 Reverse Transcriptase Promotes Tumor Growth and Metastasis Formation via ROS-Dependent Upregulation of Twist

Figure 1

Alignment of the amino acid sequences of the consensus HIV-1 reverse transcriptase and its drug resistance variants designed in the study. “RT_A,” consensus of amino acid sequences () of HIV-1 subtype A FSU_A strain isolated between 1999 and 2012, with amino acids in variable positions chosen using OMES-based covariance network. “RT_An,” RT_A variant with introduced mutations of resistance to NRTI K65R and M184V; “RT_Ann,” RT_A variant with introduced mutations of resistance to NNRTI K103N and G190S; “K03455.1 HIV-1 subtype B (HXB2),” reference sequence of HIV-1 subtype B RT used for position numbering [63].