HIV-1 Reverse Transcriptase Promotes Tumor Growth and Metastasis Formation via ROS-Dependent Upregulation of Twist

Figure 9

Histochemical characterization of the solid tumors formed by the parental 4T1luc2 cells (a) and their derivatives expressing variants of HIV-1 FSU_A reverse transcriptase (RT_A) after ectopic implantation into BALB/c mice: 4T1luc2_RT-1.3 (b), 4T1luc2_RT-5.3 (c), 4T1luc2_RT-20.1 (d), 4T1luc2_RT-An-1.4 (e), 4T1luc2_RT-An-10.1 (f); 4T1luc2_RT-Ann-1.5 (g), 4T1luc2_RT-Ann-10.2 (h). H&E staining: magnification ×400.

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