HIV-1 Reverse Transcriptase Promotes Tumor Growth and Metastasis Formation via ROS-Dependent Upregulation of Twist

Table 1

Kinetic parameters of the polymerase and RNase H activity of the variants of consensus RT of HIV-1 clade A FSU_A compared to RT of HIV-1 clade B HXB2 strain.

HIV-1 RT variants	Polymerase activity		RNase H activity
	(nM)	RT (μM/secmg)	(nM)	RT (μM/secmg)
Wild-type RT of subtype B HXB2 strain (RT_B)
Consensus RT of subtype A (RT_A)		>RT_B		<RT_B ()
Consensus RT of subtype A with primary mutations of resistance to nucleoside inhibitors K65R and M184 (RT_An)		<RT_A (); <RT_Ann ()		<RT_B ()
Consensus RT of subtype A with primary mutations of resistance to nonnucleoside inhibitors K103N and G190S (RT_Ann)		>RT_B (); >RT_An ()		<RT_B (); ≤RT_A ()

Results presented as in triplicate tests. Significance of difference assessed by Fisher LSD test.