Oxidative Stress-Driven Autophagy acROSs Onset and Therapeutic Outcome in Hepatocellular Carcinoma

<div>Scheme representing the sources of oxidative stress (underlined) that through direct oxidation affect the function (parenthesis) of key proteins (ellipse) involved in cell death/proliferation, autophagy, and migration/invasiveness, which are pathways commonly altered in cancer. PDGF: platelet-derived growth factor; EGF: epidermal growth factor; PMA: phorbol myristate acetate; TNF<i>α</i>: tumor necrosis factor <i>α</i>; PIP<sub>3</sub>: phosphatidylinositol 3,4,5 trisphosphate; ECM: extracellular matrix.</div>

Oxidative Medicine and Cellular Longevity

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Figure 1

Figure 1: Oxidative Stress-Driven Autophagy acROSs Onset and Therapeutic Outcome in Hepatocellular Carcinoma 