Oxidative Stress-Driven Autophagy acROSs Onset and Therapeutic Outcome in Hepatocellular Carcinoma

Table 1

Main ROS sources/antioxidants and their localization.

Endogenous ROS sources	Main localization	Antioxidants	Main localization
NADPH oxidase	Plasma membrane	Glutathione	Ubiquitous
Respiratory complexes I and III	Mitochondrion	α-Tocopherol	Plasma membrane
CYP450	Endoplasmic reticulum	Superoxide dismutase	Mitochondrion/cytosol
Xanthine oxidase	Cytosol/peroxisome	Catalase	Peroxisome
Peroxisomal oxidases	Peroxisome	Thioredoxin	Nucleus/mitochondrion
Lipoxygenase/cyclooxygenase	Cytosol	Glutathione peroxidase	Cytosol/mitochondrion/plasma membrane