Andrographolide Derivative AL-1 Ameliorates Dextran Sodium Sulfate-Induced Murine Colitis by Inhibiting NF-κB and MAPK Signaling Pathways

Figure 2

AL-1 suppresses the inflammatory responses in acute colitis after DSS administration. (a) IHC for Gr-1 showing the numbers of accumulated neutrophils in the acutely injured mouse colonic mucosa. (b) IHC for CD3 showing infiltration of T-lymphocytes, especially around the crypts in the lamina propria. (c) IHC for Mac-2 showing the number of perimucosal macrophages in the mice. . Data are presented as the (, 3 male and 3 female mice). compared with the control group and ^#, ^##, and ^### compared with the vehicle-treated UC model group.

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