Andrographolide Derivative AL-1 Ameliorates Dextran Sodium Sulfate-Induced Murine Colitis by Inhibiting NF-κB and MAPK Signaling Pathways

Figure 9

Proposed AL-1 mechanism of action in the mouse model of colitis. AL-1 inhibits both NF-κB and MAPK activation to decrease protein and mRNA levels of proinflammatory cytokines and alleviate colitis.