Research Article
HB-EGF Ameliorates Oxidative Stress-Mediated Uterine Decidualization Damage
Figure 8
HB-EGF prevents the apoptosis of uterine stromal cells after exposure to H2O2. (a and b) NAC and HB-EGF blocked the induction of H2O2 on stromal cell apoptosis. After treatment with NAC or rHB-EGF and then addition of H2O2, cell apoptosis was determined by flow cytometry. (c) NAC and HB-EGF blocked the stimulation of H2O2 on Caspase-3 activity. (d) NAC and HB-EGF hindered the stimulation of H2O2 on Bax mRNA expression. (e) NAC and HB-EGF canceled the repression of H2O2 on Bcl-2 mRNA expression. (f) NAC and HB-EGF weakened the stimulation of H2O2 on Caspase-3 mRNA expression.
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