DPP4 Inhibitor Attenuates Severe Acute Pancreatitis-Associated Intestinal Inflammation via Nrf2 Signaling

Figure 3

The alteration of oxidative stress responses and Nrf2-mediated signaling pathway in sitagliptin-treated SAP mice. The pancreas and intestine tissues were harvested 24 h after the last intraperitoneal injection. (a) Concentration of MDA in intestinal tissue from the different groups. (b) Activity of SOD in the intestinal tissue from the different groups. (c) Real-time PCR results of DPP4, Nrf2, and NF-κB in different groups. (d) Western blotting results of DPP4, Nrf2, and NF-κB in different groups. Data are presented as error of the mean (SEM) (). , compared with the N group. , compared with the SAP group. N, the control group; SAP, the severe acute pancreatitis group; SAP+SIT 100, the severe acute pancreatitis+100 μM sitagliptin group; SAP+SIT 200, the severe acute pancreatitis+200 μM sitagliptin group.

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