Myricetin Alleviates Pathological Cardiac Hypertrophy via TRAF6/TAK1/MAPK and Nrf2 Signaling Pathway

Figure 1

Myr treatment attenuated cardiac hypertrophy and fibrosis. (a) Gross image of the heart; (b) calculated cardiomyocyte across the area of HE staining; (c) Myr prevented the downregulation of α-MHC; (d) Myr inhibited the expression of ANP, BNP, and β-MHC; (e) Myr inhibited interstitial and perivascular fibrosis in mouse heart; (f) calculated LV collagen volume of PSR staining; (g) Myr inhibited the expression of fibrosis-associated markers, for staining experiments, for mRNA determination, versus the CON group or the Myr group, ^# versus the AB+Myr group.

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