Neuroglobin: A Novel Player in the Oxidative Stress Response of Cancer Cells

Figure 2

(a) Schematic model of ROS-activated signaling involved in the rapid modulation of NGB levels, its localization, and function on the redox balance outside mitochondria. (b) Schematic model of the E2 intracellular-activated pathway impacting on NGB expression, localization, and the NRF-2 pathway describing how NGB affects the E2-dependent activation of the antioxidant NRF-2 system. E2: 17β-estradiol; ERα: estrogen receptor α; PI3K: phosphatidylinositol 3 kinase. For further detail, see the text.