Research Article
Increased HIF-1α in Knee Osteoarthritis Aggravate Synovial Fibrosis via Fibroblast-Like Synoviocyte Pyroptosis
Figure 2
HIF-1α inhibitor attenuated synovial fibrosis in rats. (a) The severity of synovial fibrosis evaluated by the transverse diameters of the right knees. vs. the Normal group; vs. the KOA+Digoxin group. (b) Anatomical changes of each group. (c) Representative synovial tissues of each group stained with HE and Sirius Red staining, 200x, scale . Disorderly arranged synovial lining cells, inflammatory cell infiltration, and increased collagen deposition could be observed in the KOA group. (d) Relative gene expression of TGF-β, COL1A1, PLOD2, and TIMP1 in synovial tissues of rats in each group. vs. the Normal group; vs. the KOA group. (e) Typical protein bands for each group. (f) The same trend with gene level can also be observed in the relative protein level.
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