Mitophagy and Oxidative Stress in Cancer and Aging: Focus on Sirtuins and Nanomaterials

Figure 5

Schematic representation of all the aspects related to mitophagy. Two basic mechanisms have been elucidated involving a different set of molecules in relation to the prototype damage: the mitochondrial depolarization and hypoxia, starvation, and genes controlled by some master transcription factors (p53, RB/E2F, FoxOS, NFkB, sirtuins, and others).