Mitophagy and Oxidative Stress in Cancer and Aging: Focus on Sirtuins and Nanomaterials

Table 3

Markers of mitophagy.

Marker	Localization	Species	Reference
Aup1	Mitochondrial intermembrane space	Yeast	[2]
Uth1	Cytoplasmic leaflet of the outer mitochondrial membrane	Yeast	[3]
LGG-1	Membrane of phagophore and autophagosome	Yeast	[51]
PINK1	Normally undetectable, stabilized on the outer mitochondrial membrane when mitochondria are depolarized	Mammals	[52]
Parkin	Normally in cytosol, it is translocated to the outer mitochondrial membrane when mitochondria are depolarized	Mammals	[30]
LC3-II	Cytosolic, during autophagy, recruited to form autophagosomal membranes	Mammals	[53]
p62	Parkin recruited to mitochondria	Mammals	[54]
TOM20	Outer mitochondrial membrane	Mammals	[38]
TIM23	Inner mitochondrial membrane	Mammals	[27]
CypD (cyclophilin D)	Mitochondrial matrix	Mammals	[55]
HSP60	Mitochondrial matrix	Mammals	[55]
ULK1	Recruited to fragmented mitochondria in response to hypoxia or FCCP	Mammals	[56]
SMURF1	Cytoplasmatic, colocalized with damaged mitochondria	Mammals	[57]
Mitofusins 1/2	Mitochondrial outer membrane	Mammals	[58]