Research Article

Candidate Animal Disease Model of Elizabethkingia Spp. Infection in Humans, Based on the Systematic Pathology and Oxidative Damage Caused by E. miricola in Pelophylax nigromaculatus

Table 1

Histopathological assessment. An importance factor (), ranging from 1 to 3, was assigned to every change (1—minimal pathological importance: the lesion is easily reversible as exposure to irritants ends; 2—moderate pathological importance: the lesion is reversible in most cases if the stressor is neutralized; and 3—marked pathological importance: the lesion is generally irreversible, leading to partial or total loss of the organ function [26]).

Organ (Org)Functional unit of the tissue ()Alteration (alt)Importance factor ()

KidneyTubule/glomerulus/interstitial tissue
LiverLiver tissue/interstitial tissueHaemorrhage1
HeartEpicardial/myocardium/cardiac chamberHyperaemia
LungAlveolar/capillariesEdema1
SpleenInterstitial tissue/sinusoidDeposition1
MuscleMuscle fiber/connective tissueHypertrophy1
BrainMeninges/brain parenchymaHyperplasia2
SpineNerve tissue/muscle tissue/connective tissueAtrophy2
EyeRetina/corneaInfiltration2
StomachMucosa/smooth muscle layerNecrosis3
IntestinalMucosa/lamina propria/smooth muscle layer