TRPA1 Promotes Cardiac Myofibroblast Transdifferentiation after Myocardial Infarction Injury via the Calcineurin-NFAT-DYRK1A Signaling Pathway

Figure 8

Schematic of the proposed mechanism underlying TRPA1-mediated CMF transdifferentiation and cardiac fibrosis after MI injury. Signaling model for CMF transdifferentiation whereby MI injury upregulates TRPA1 expression, enhancing Ca²⁺ entry and leading to CaN activation, resulting in the translocation of NFAT to the nucleus to participate in CMF phenotypic conversion. DYRK1A, as the downstream signaling effector of TRPA1, mediates NFAT transcription factors as likely regulators of CMF transdifferentiation-related gene expression.