Antitumoral and Immunomodulatory Effect of Mahonia aquifolium Extracts
Table 1
The in vitro effect of M. aquifolium extracts 1-5 on CD25 membrane marker and intracellular IL-10 expression in CD4+, CD8+, CD14+, and CD19+ cells.
Cell types
Q1—CD25 FITC
Q2—CD25 FITC/IL-10 PE
Q4—IL10 PE
Median values
SD
Median values
SD
Median values
SD
CD4+
Untreated
23.5
0.71
62.5
2.12
86.5
2.12
Extract 1
301.0
12.73
1108.5
4.95
53.0
1.41
Extract 2
12.0
1.41
57.5
3.54
113.5
7.78
Extract 3
12.0
2.83
180.5
0.71
333.0
2.83
Extract 4
17.5
3.54
154.5
6.36
243.0
12.73
Extract 5
7.5
0.71
136.5
2.12
158.5
2.12
CD8+
Untreated
3.0
0.00
58.0
2.89
162.5
9.19
Extract 1
119.5
0.71
396.0
1.41
113.0
0.00
Extract 2
2.0
0.00
114.5
6.36
122.0
0.00
Extract 3
1.5
0.71
61.5
0.71
148.0
4.24
Extract 4
1.0
0.00
55.5
6.36
95.5
0.71
Extract 5
2.5
0.71
97.0
0.00
91.5
0.71
CD14+
Untreated
51.0
1.41
268.0
2.83
349.0
1.41
Extract 1
310.5
0.71
1131.0
1.41
71.5
2.12
Extract 2
9.5
0.61
129.5
0.71
248.0
2.83
Extract 3
12.5
2.12
188.0
2.83
320.0
12.73
Extract 4
22.5
3.55
167.5
3.54
179.5
2.12
Extract 5
8.5
2.12
189.5
2.12
188.0
2.83
CD19+
Untreated
90.0
0.00
209.0
1.41
118.5
9.19
Extract 1
81.0
1.41
582.5
3.54
241.5
7.78
Extract 2
11.5
2.12
322.0
2.83
290.5
0.71
Extract 3
33.0
2.83
358.0
5.66
230.0
0.00
Extract 4
29.0
1.41
481.5
9.19
338.5
4.95
Extract 5
21.0
1.41
359.5
0.71
232.5
3.54
Extremely significant differences between treated cells vs. untreated control, . Very significant differences between treated cells vs. untreated control, . Significant differences between treated cells vs. untreated control, .
