Nitric Oxide Metabolites and Lung Cancer Incidence: A Matched Case-Control Study Nested in the ESTHER Cohort

Table 3

Associations of nitrite/nitrate concentration quintiles with lung cancer incidence, the ESTHER study (2000-2014).

	Nitrite/nitrate levels (μmol/mmol creatinine)		Main model^a; OR (95% CI)	Sensitivity model 1^b; OR (95% CI)	Sensitivity model 2^c; OR (95% CI)
Quintile 1	<66.9	48/147	Ref.	Ref.	Ref.
Quintile 2	66.9 - <97.2	39/147	0.81 (0.59-1.12)	0.81 (0.59-1.12)	0.82 (0.60-1.12)
Quintile 3	97.2 - <134.1	43/147	0.88 (0.65-1.20)	0.89 (0.65-1.21)	0.88 (0.65-1.20)
Quintile 4	134.1 - <192.8	48/147	1.00 (0.74-1.36)	1.01 (0.75-1.37)	1.01 (0.74-1.36)
Quintile 5	≥192.8	67/147	1.37 (1.04-1.82)	1.38 (1.04-1.82)	1.36 (1.03-1.80)

^aAdjusted for body mass index (BMI), education, family history of lung cancer, asthma, physical activity, and vegetable and meat consumption frequency. In addition, potential confounding by the following factors was controlled by matching age, sex, smoking status, and pack-years of smoking. ^bAdjusted for variables of the main model+C-reactive protein. In addition, potential confounding by the following factors was controlled by matching age, sex, smoking status, and pack-years of smoking. ^cAdjusted for variables of the main model+8-isoprostane. In addition, potential confounding by the following factors was controlled by matching age, sex, smoking status, and pack-years of smoking. Note: numbers in bold: statistically significant estimates compared to the quintile 1 ().