Subchronic Exposure to Cadmium Causes Persistent Changes in the Reproductive System in Female Wistar Rats
Table 3
Oxidative stress biomarkers in rats after oral exposure to CdCl2 or 17β-estradiol (positive control) exposure and 90- and 180-day postexposure periods in comparison to controls.
Treatment
Doses (mg/kg b.w.)
TAS in plasma (mM)
GSH in uterus (μmol/g)
CAT in uterus (U/mg protein)
MDA in uterus (nmol/g)
Group A (90-day exposure)
Pure control
0
Cd
0.09
Cd
0.9
Cd
1.8
a
Cd
4.5
a,b,c
a,b,c
Oil control
0
Positive control
0.03
b
Group B (90-day exposure and 90-day postexposure periods)
Pure control
0
Cd
0.09
Cd
0.9
Cd
1.8
Cd
4.5
a
Oil control
0
Positive control
0.03
Group C (90-day exposure and 180-day postexposure periods)
Pure control
0
Cd
0.09
Cd
0.9
Cd
1.8
Cd
4.5
a,b,c
Oil control
0
Positive control
0.03
All values are expressed as .a, significantly different from control pure animals. b, significantly different from oil control, c, significantly different from positive control.