Subchronic Exposure to Cadmium Causes Persistent Changes in the Reproductive System in Female Wistar Rats

Table 3

Oxidative stress biomarkers in rats after oral exposure to CdCl₂ or 17β-estradiol (positive control) exposure and 90- and 180-day postexposure periods in comparison to controls.

Treatment	Doses; (mg/kg b.w.)	TAS in plasma; (mM)	GSH in uterus; (μmol/g)	CAT in uterus; (U/mg protein)	MDA in uterus; (nmol/g)
Group A (90-day exposure)
Pure control	0
Cd	0.09
Cd	0.9
Cd	1.8				^a
Cd	4.5			^a,b,c	^a,b,c
Oil control	0
Positive control	0.03	^b
Group B (90-day exposure and 90-day postexposure periods)
Pure control	0
Cd	0.09
Cd	0.9
Cd	1.8
Cd	4.5				^a
Oil control	0
Positive control	0.03
Group C (90-day exposure and 180-day postexposure periods)
Pure control	0
Cd	0.09
Cd	0.9
Cd	1.8
Cd	4.5				^a,b,c
Oil control	0
Positive control	0.03

All values are expressed as . ^a, significantly different from control pure animals. ^b, significantly different from oil control, ^c, significantly different from positive control.