Triptolide Inhibits Preformed Fibril-Induced Microglial Activation by Targeting the MicroRNA155-5p/SHIP1 Pathway

Figure 5

miR155-5p regulated NF-κB activity by the PI3K/Akt pathway. (a-d) Primary microglia were cotreated with miR155-5p inhibitors and PFFs for 24 h and harvested for analysis. Ratios of p-PI3K/PI3K, p-Akt/t-Akt, p-IKKα/β/IKKα/β, and p-NF-κB/NF-κB were measured by Western blot, and representative images are shown. (e) Phosphorylation of NF-κB was evaluated after treatment of miR155-5p mimics. The values were expressed as . and .