T Cell-Derived IL-17A Induces Vascular Dysfunction via Perivascular Fibrosis Formation and Dysregulation of ^⋅NO/cGMP Signaling

Figure 1

Overexpression of IL-17A in T cells results in vascular dysfunction per se. (a) Cytokine profile of CD4-IL-17A^ind/+ mice in plasma measured with a Bio-Plex assay kit. IL-17A^ind/+ control mice were normalized to 100% (indicated with the dashed line); percentual change compared to control is shown for CD4-IL-17A^ind/+ mice; ; either Student’s unpaired -test or Mann–Whitney -test. (b) Cumulative concentration relaxation curves of aortic rings of CD4-IL-17A^ind/+ and IL-17A^ind/+ control mice in response to ACh (b1) and GTN (b2); ; two-way ANOVA with Bonferroni post hoc test. (c) Maximal aortic constriction in response to a phenylephrine bolus in organ chamber from CD4-IL-17A^ind/+ and IL-17A^ind/+ control mice; ; Student’s unpaired -test. (d) Cardiac function measured via echocardiography; ; Student’s unpaired -test. (e) Systolic blood pressure detection via carotid artery telemetry catheter implantation of mice over 48 hours; . Data (a–d) are presented as .

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