Prooxidative Activity of Celastrol Induces Apoptosis, DNA Damage, and Cell Cycle Arrest in Drug-Resistant Human Colon Cancer Cells

Figure 1

Intracellular ROS level (DCF-DA assay) in LOVO/DX cells compared to LOVO cells. (a) Representative histograms of flow cytometric evaluation of the cell-associated DCF fluorescence. (b) The basal level of intracellular ROS in LOVO/DX cells compared to LOVO cells. Results are expressed as (, , ), where the MFI (mean fluorescent intensity) of DCF in LOVO/DX cells () was compared to the MFI in LOVO cells ().

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