Prooxidative Activity of Celastrol Induces Apoptosis, DNA Damage, and Cell Cycle Arrest in Drug-Resistant Human Colon Cancer Cells
The frequency of necrotic cells in LOVO/DX cell cultures incubated with celastrol (a) and coincubated with celastrol and NAC (b). The cells were double stained with Annexin V-FITC and propidium iodide (PI) fluorescent dyes (FITC Annexin V Apoptosis Detection Kit) and analyzed by flow cytometry. Control: LOVO/DX cells incubated without celastrol (gray), LOVO/DX cells incubated without celastrol and NAC (black). The results are presented as a percentage of PI+ cells (Annexin V-FITC- and PI+ dead cells); ,,,.
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