Prooxidative Activity of Celastrol Induces Apoptosis, DNA Damage, and Cell Cycle Arrest in Drug-Resistant Human Colon Cancer Cells

<div>Impact of celastrol on cell cycle distribution in LOVO/DX cells. (a) Representative histograms of flow cytometric analysis of cell cycle. (b) Bar graph showing the percentage of LOVO/DX cells in each cell cycle phase after incubation with solvent (DMSO) or celastrol. 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Oxidative Medicine and Cellular Longevity

fig7

Figure 7

Figure 7: Prooxidative Activity of Celastrol Induces Apoptosis, DNA Damage, and Cell Cycle Arrest in Drug-Resistant Human Colon Cancer Cells 