Oxidative Medicine and Cellular Longevity / 2019 / Article / Fig 8

Research Article

Prooxidative Activity of Celastrol Induces Apoptosis, DNA Damage, and Cell Cycle Arrest in Drug-Resistant Human Colon Cancer Cells

Figure 8

Representative histograms of flow cytometric analysis of DNA damages (γ-H2AX+ cells) and cell cycle phases in LOVO/DX cells after treatment with celastrol. (a) Detection of γ-H2AX+ cells using phospho-histone H2A.X (Ser139) monoclonal antibody (CR55T33) Alexa Fluor 488. SSC = side light scatter. (b) Bivariant cell cycle/DAPI-combined γ-H2AX analysis.

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.