Prooxidative Activity of Celastrol Induces Apoptosis, DNA Damage, and Cell Cycle Arrest in Drug-Resistant Human Colon Cancer Cells

Table 2

Effect of celastrol on the number of γ-H2AX⁺ cells in different phases of cell cycle in LOVO/DX cell culture.

	γ-H2AX^+ cells in cell cycle phases (%)
	G1	S	G2/M
CEL 1 μM	0.29	0.18	0.32
CEL 2.5 μM	3.85	4.95	7.48
CEL 5 μM	8.69	6.97	9.73
CEL 20 μM	0.11	0.12	0.13
NAC	0.37	0.36	0.38
CEL 5 μM+NAC	0.58	0.53	0.57