Increased Oxidative Stress Induced by Rubus Bioactive Compounds Induce Apoptotic Cell Death in Human Breast Cancer Cells

Figure 11

Proposed cell death mechanism. An illustration of proposed cell death induced by C1 and C2 in MCF-7 cells. Mitochondria mediated caspase-dependent intrinsic apoptotic pathway is upregulated. Increased expression of p53, caspase 9, cleaved PARP, and Bax proteins mediated the cell death.